Neuromuscular relaxants — 1997

Neuromuscular relaxants--1997.

T HE sixth International Neuromuscular Meeting was held in Paris in August. The original meeting, in London in 1975, was to act as a forum for investigators and industry (Burroughs Wellcome and Organon) in the hope that such a liaison would lead to the development of muscle relaxants needed by the clinician. In so far as the intermediate relaxants, atracttrium and vecuronium, were developed, th...

Changes in resistance to mouth opening induced by depolarizing and non-depolarizing neuromuscular relaxants.

Mouth opening was measured in 43 children anaesthetized with isoflurane and paralysed with vecuronium or suxamethonium. Measurements of mouth opening were made for up to 10 min after loss of the adductor pollicis twitch and cessation of muscle fasciculations. In 22 patients receiving suxamethonium, a significant (P less than 0.001) reduction in mean mouth opening occurred in the 60 s after loss...

Streptozotocin Diabetes Attenuates the Effects of Nondepolarizing Neuromuscular Relaxants on Rat Muscles

The hypothesis of this study was that diabetes-induced desensitization of rat soleus (SOL) and extensor digitorum longus (EDL) to non-depolarizing muscle relaxants (NDMRs) depends on the stage of diabetes and on the kind of NDMRs. We tested the different magnitude of resistance to vecuronium, cisatracurium, and rocuronium at different stages of streptozotocin (STZ)-induced diabetes by the EDL s...

Uterine Stimulants and Relaxants

The physiological processes involved in parturition (i.e., labor, delivery, and birth) require a complex interplay of hormonal action, neuronal activity, and uterine smooth muscle contraction. During the first two trimesters of pregnancy, the uterus remains in a relatively quiescent state, demonstrating little or no contraction of the myometrium.This inactivity is largely the result of the inhi...

Use of muscle relaxants.